Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 7
Ligand
BDBM74478
Substrate
n/a
Meas. Tech.
Dose Response confirmation of HTS hits from an HePTP Fluorescent Assay using OMFP substrate - Set 2
IC50
>79400±0 nM
Citation
 PubChem, PC Dose Response confirmation of HTS hits from an HePTP Fluorescent Assay using OMFP substrate - Set 2 PubChem Bioassay (2010)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 7
Synonyms:
He-PTP | Hematopoietic protein-tyrosine phosphatase | Hematopoietic protein-tyrosine phosphatase (HEPTP) | PTN7_HUMAN | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7 | Tyrosine-protein phosphatase non-receptor type 7 (HEPTP)
Type:
Protein
Mol. Mass.:
40530.79
Organism:
Homo sapiens (Human)
Description:
P35236
Residue:
360
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
  
Inhibitor
Name:
BDBM74478
Synonyms:
2,3-Dimethoxy-6-{[2-(4-methoxy-phenoxy)-acetyl]-hydrazonomethyl}-benzoic acid | 2,3-dimethoxy-6-[[2-(4-methoxyphenoxy)ethanoylhydrazinylidene]methyl]benzoic acid | 2,3-dimethoxy-6-[[[2-(4-methoxyphenoxy)-1-oxoethyl]hydrazinylidene]methyl]benzoic acid | 2,3-dimethoxy-6-[[[2-(4-methoxyphenoxy)acetyl]hydrazinylidene]methyl]benzoic acid | 2,3-dimethoxy-6-[[[2-(4-methoxyphenoxy)acetyl]hydrazono]methyl]benzoic acid | MLS000588686 | SMR000212264 | cid_1901725
Type:
Small organic molecule
Emp. Form.:
C19H20N2O7
Mol. Mass.:
388.3713
SMILES:
COc1ccc(OCC(=O)NN=Cc2ccc(OC)c(OC)c2C(O)=O)cc1
Structure:
Search PDB for entries with ligand similarity: