Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 3
Ligand
BDBM75361
Substrate
n/a
Meas. Tech.
SAR analysis of compounds that inhibit VHR1, Fluorescent Assay - Set 2
IC50
37900±n/a nM
Citation
 PubChem, PC SAR analysis of compounds that inhibit VHR1, Fluorescent Assay - Set 2 PubChem Bioassay (2010)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM75361
Synonyms:
4-amino-3-(2-fluoro-5-methyl-phenyl)-N-(p-tolyl)-2-thioxo-4-thiazoline-5-carboxamide | 4-amino-3-(2-fluoro-5-methylphenyl)-N-(4-methylphenyl)-2-sulfanylidene-1,3-thiazole-5-carboxamide | 4-amino-3-(2-fluoro-5-methylphenyl)-N-(4-methylphenyl)-2-sulfanylidene-5-thiazolecarboxamide | 4-azanyl-3-(2-fluoranyl-5-methyl-phenyl)-N-(4-methylphenyl)-2-sulfanylidene-1,3-thiazole-5-carboxamide | MLS-0237139.0001 | cid_4073188
Type:
Small organic molecule
Emp. Form.:
C18H16FN3OS2
Mol. Mass.:
373.468
SMILES:
Cc1ccc(NC(=O)c2sc(=S)n(c2N)-c2cc(C)ccc2F)cc1 |(10.46,7.31,;9.56,6.07,;10.18,4.66,;9.28,3.41,;7.74,3.58,;6.84,2.33,;7.47,.92,;9,.76,;6.56,-.32,;5.02,-.32,;4.54,-1.79,;3.08,-2.26,;5.79,-2.69,;7.04,-1.79,;8.5,-2.26,;5.79,-4.23,;7.12,-5,;7.12,-6.54,;8.46,-7.31,;5.79,-7.31,;4.46,-6.54,;4.46,-5,;3.12,-4.23,;7.12,4.98,;8.02,6.23,)|
Structure:
Search PDB for entries with ligand similarity: