Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 7
Ligand
BDBM75358
Substrate
n/a
Meas. Tech.
SAR analysis of compounds that inhibit HePTP - Set 2
IC50
100000±n/a nM
Citation
 PubChem, PC SAR analysis of compounds that inhibit HePTP - Set 2 PubChem Bioassay (2010)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 7
Synonyms:
He-PTP | Hematopoietic protein-tyrosine phosphatase | Hematopoietic protein-tyrosine phosphatase (HEPTP) | PTN7_HUMAN | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7 | Tyrosine-protein phosphatase non-receptor type 7 (HEPTP)
Type:
Protein
Mol. Mass.:
40530.79
Organism:
Homo sapiens (Human)
Description:
P35236
Residue:
360
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
  
Inhibitor
Name:
BDBM75358
Synonyms:
MLS-0435608.0001 | [4-amino-3-(2,5-dimethylphenyl)-2-sulfanylidene-1,3-thiazol-5-yl]-piperidin-1-ylmethanone | [4-amino-3-(2,5-dimethylphenyl)-2-sulfanylidene-5-thiazolyl]-(1-piperidinyl)methanone | [4-amino-3-(2,5-dimethylphenyl)-2-thioxo-4-thiazolin-5-yl]-piperidino-methanone | [4-azanyl-3-(2,5-dimethylphenyl)-2-sulfanylidene-1,3-thiazol-5-yl]-piperidin-1-yl-methanone | cid_44620972
Type:
Small organic molecule
Emp. Form.:
C17H21N3OS2
Mol. Mass.:
347.498
SMILES:
Cc1ccc(C)c(c1)-n1c(N)c(sc1=S)C(=O)N1CCCCC1 |(8.46,-6.23,;7.12,-5.46,;5.79,-6.23,;4.46,-5.46,;4.46,-3.92,;3.12,-3.15,;5.79,-3.15,;7.12,-3.92,;5.79,-1.61,;7.04,-.7,;8.5,-1.18,;6.56,.76,;5.02,.76,;4.54,-.7,;3.08,-1.18,;7.47,2.01,;9,1.85,;6.84,3.41,;5.31,3.58,;4.68,4.98,;5.59,6.23,;7.12,6.07,;7.74,4.66,)|
Structure:
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