Reaction Details Report a problem with these data
Target
Kappa-type opioid receptor
Ligand
BDBM75434
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 3
EC50
>20000±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 3 PubChem Bioassay (2010)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM75434
Synonyms:
2-[5-[(4-bromobenzyl)thio]-4-p-anisyl-1,2,4-triazol-3-yl]pyridine | 2-[5-[(4-bromophenyl)methylsulfanyl]-4-[(4-methoxyphenyl)methyl]-1,2,4-triazol-3-yl]pyridine | 2-[5-[(4-bromophenyl)methylthio]-4-[(4-methoxyphenyl)methyl]-1,2,4-triazol-3-yl]pyridine | KSC-12-171B2-2 | KUC105596N | cid_45479191
Type:
Small organic molecule
Emp. Form.:
C22H19BrN4OS
Mol. Mass.:
467.381
SMILES:
COc1ccc(Cn2c(SCc3ccc(Br)cc3)nnc2-c2ccccn2)cc1
Structure:
Search PDB for entries with ligand similarity: