Reaction Details Report a problem with these data
Target
Nuclear receptor subfamily 1 group I member 2
Ligand
BDBM37443
Substrate
n/a
Meas. Tech.
Luminescence-based counterscreen for activators of the Aryl Hydrocarbon Receptor (AHR): cell-based high throughput dose response screening assay for activators of the Pregnane X Receptor (PXR)
EC50
>116159±n/a nM
Citation
 PubChem, PC Luminescence-based counterscreen for activators of the Aryl Hydrocarbon Receptor (AHR): cell-based high throughput dose response screening assay for activators of the Pregnane X Receptor (PXR) PubChem Bioassay (2010)[AID] 
Target
Name:
Nuclear receptor subfamily 1 group I member 2
Synonyms:
NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1
Type:
Nuclear receptor
Mol. Mass.:
49774.77
Organism:
Homo sapiens (Human)
Description:
O75469
Residue:
434
Sequence:
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
  
Inhibitor
Name:
BDBM37443
Synonyms:
6-(1,3-benzothiazol-2-yl)-2-N,2-N-dimethyl-1,3,5-triazine-2,4-diamine | 6-(1,3-benzothiazol-2-yl)-N,N-dimethyl-1,3,5-triazine-2,4-diamine | 6-(1,3-benzothiazol-2-yl)-N2,N2-dimethyl-1,3,5-triazine-2,4-diamine | MLS000099945 | SMR000081123 | [4-amino-6-(1,3-benzothiazol-2-yl)-s-triazin-2-yl]-dimethyl-amine | cid_1249482
Type:
Small organic molecule
Emp. Form.:
C12H12N6S
Mol. Mass.:
272.329
SMILES:
CN(C)c1nc(N)nc(n1)-c1nc2ccccc2s1
Structure:
Search PDB for entries with ligand similarity: