Reaction Details Report a problem with these data
Target
Nuclear receptor subfamily 1 group I member 2
Ligand
BDBM75517
Substrate
n/a
Meas. Tech.
Luminescence-based counterscreen for activators of the Aryl Hydrocarbon Receptor (AHR): cell-based high throughput dose response screening assay for activators of the Pregnane X Receptor (PXR)
EC50
48063±n/a nM
Citation
 PubChem, PC Luminescence-based counterscreen for activators of the Aryl Hydrocarbon Receptor (AHR): cell-based high throughput dose response screening assay for activators of the Pregnane X Receptor (PXR) PubChem Bioassay (2010)[AID] 
Target
Name:
Nuclear receptor subfamily 1 group I member 2
Synonyms:
NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1
Type:
Nuclear receptor
Mol. Mass.:
49774.77
Organism:
Homo sapiens (Human)
Description:
O75469
Residue:
434
Sequence:
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
  
Inhibitor
Name:
BDBM75517
Synonyms:
6-Chloro-N-(4-chloro-phenyl)-N'-propyl-[1,3,5]triazine-2,4-diamine | 6-chloranyl-N2-(4-chlorophenyl)-N4-propyl-1,3,5-triazine-2,4-diamine | 6-chloro-2-N-(4-chlorophenyl)-4-N-propyl-1,3,5-triazine-2,4-diamine | 6-chloro-N2-(4-chlorophenyl)-N4-propyl-1,3,5-triazine-2,4-diamine | MLS001207726 | SMR000514165 | [4-chloro-6-(4-chloroanilino)-s-triazin-2-yl]-propyl-amine | cid_3107863
Type:
Small organic molecule
Emp. Form.:
C12H13Cl2N5
Mol. Mass.:
298.171
SMILES:
CCCNc1nc(Cl)nc(Nc2ccc(Cl)cc2)n1
Structure:
Search PDB for entries with ligand similarity: