Reaction Details Report a problem with these data
Target
Aryl hydrocarbon receptor
Ligand
BDBM75483
Substrate
n/a
Meas. Tech.
Luminescence-based cell-based high throughput dose response assay for activators of the Aryl Hydrocarbon Receptor (AHR)
EC50
8496±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay for activators of the Aryl Hydrocarbon Receptor (AHR) PubChem Bioassay (2010)[AID] 
Target
Name:
Aryl hydrocarbon receptor
Synonyms:
AHR | AHR_HUMAN | BHLHE76 | Class E basic helix-loop-helix protein 76 | aryl hydrocarbon receptor precursor
Type:
PROTEIN
Mol. Mass.:
96143.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1503828
Residue:
848
Sequence:
MNSSSANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPTERNGGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPPENSPLMERCFICRLRCLLDNSSGFLAMNFQGKLKYLHGQKKKGKDGSILPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRWTWVQSNARLLYKNGRPDYIIVTQRPLTDEEGTEHLRKRNTKLPFMFTTGEAVLYEATNPFPAIMDPLPLRTKNGTSGKDSATTSTLSKDSLNPSSLLAAMMQQDESIYLYPASSTSSTAPFENNFFNESMNECRNWQDNTAPMGNDTILKHEQIDQPQDVNSFAGGHPGLFQDSKNSDLYSIMKNLGIDFEDIRHMQNEKFFRNDFSGEVDFRDIDLTDEILTYVQDSLSKSPFIPSDYQQQQSLALNSSCMVQEHLHLEQQQQHHQKQVVVEPQQQLCQKMKHMQVNGMFENWNSNQFVPFNCPQQDPQQYNVFTDLHGISQEFPYKSEMDSMPYTQNFISCNQPVLPQHSKCTELDYPMGSFEPSPYPTTSSLEDFVTCLQLPENQKHGLNPQSAIITPQTCYAGAVSMYQCQPEPQHTHVGQMQYNPVLPGQQAFLNKFQNGVLNETYPAELNNINNTQTTTHLQPLHHPSEARPFPDLTSSGFL
  
Inhibitor
Name:
BDBM75483
Synonyms:
2-[2-[(5-bromanylthiophen-2-yl)methylidene]hydrazinyl]-6-methyl-1H-pyrimidin-4-one | 2-[2-[(5-bromo-2-thiophenyl)methylidene]hydrazinyl]-6-methyl-1H-pyrimidin-4-one | 2-[2-[(5-bromothiophen-2-yl)methylidene]hydrazinyl]-6-methyl-1H-pyrimidin-4-one | 2-[N'-[(5-bromo-2-thienyl)methylene]hydrazino]-6-methyl-1H-pyrimidin-4-one | 5-bromothiophene-2-carbaldehyde (4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)hydrazone | MLS000586517 | SMR000207896 | cid_5151744
Type:
Small organic molecule
Emp. Form.:
C10H9BrN4OS
Mol. Mass.:
313.174
SMILES:
Cc1cc(=O)[nH]c(N=NCc2ccc(Br)s2)n1 |w:7.6|
Structure:
Search PDB for entries with ligand similarity: