Reaction Details Report a problem with these data
Target
Insulin-degrading enzyme
Ligand
BDBM60094
Substrate
n/a
Meas. Tech.
Dose Response: Fluorescence polarization-based cell-based high throughput dose response assay for inhibitors of insulin-degrading enzyme (IDE)
IC50
18148±n/a nM
Citation
 PubChem, PC Dose Response: Fluorescence polarization-based cell-based high throughput dose response assay for inhibitors of insulin-degrading enzyme (IDE) PubChem Bioassay (2010)[AID] 
Target
Name:
Insulin-degrading enzyme
Synonyms:
Abeta-degrading protease | Human Insulin Degrading Enzyme (hIDE) | IDE | IDE_HUMAN | Insulin degrading enzyme (hIDE) | Insulin protease | Insulin-degrading enzyme | Insulinase | Insulysin | insulin-degrading enzyme isoform 1 precursor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
117968.59
Organism:
Homo sapiens (Human)
Description:
P14735
Residue:
1019
Sequence:
MRYRLAWLLHPALPSTFRSVLGARLPPPERLCGFQKKTYSKMNNPAIKRIGNHITKSPEDKREYRGLELANGIKVLLISDPTTDKSSAALDVHIGSLSDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLKQLYKIVPIKDIRNLYVTFPIPDLQKYYKSNPGHYLGHLIGHEGPGSLLSELKSKGWVNTLVGGQKEGARGFMFFIINVDLTEEGLLHVEDIILHMFQYIQKLRAEGPQEWVFQECKDLNAVAFRFKDKERPRGYTSKIAGILHYYPLEEVLTAEYLLEEFRPDLIEMVLDKLRPENVRVAIVSKSFEGKTDRTEEWYGTQYKQEAIPDEVIKKWQNADLNGKFKLPTKNEFIPTNFEILPLEKEATPYPALIKDTAMSKLWFKQDDKFFLPKACLNFEFFSPFAYVDPLHCNMAYLYLELLKDSLNEYAYAAELAGLSYDLQNTIYGMYLSVKGYNDKQPILLKKIIEKMATFEIDEKRFEIIKEAYMRSLNNFRAEQPHQHAMYYLRLLMTEVAWTKDELKEALDDVTLPRLKAFIPQLLSRLHIEALLHGNITKQAALGIMQMVEDTLIEHAHTKPLLPSQLVRYREVQLPDRGWFVYQQRNEVHNNCGIEIYYQTDMQSTSENMFLELFCQIISEPCFNTLRTKEQLGYIVFSGPRRANGIQGLRFIIQSEKPPHYLESRVEAFLITMEKSIEDMTEEAFQKHIQALAIRRLDKPKKLSAECAKYWGEIISQQYNFDRDNTEVAYLKTLTKEDIIKFYKEMLAVDAPRRHKVSVHVLAREMDSCPVVGEFPCQNDINLSQAPALPQPEVIQNMTEFKRGLPLFPLVKPHINFMAAKL
  
Inhibitor
Name:
BDBM60094
Synonyms:
2-[3-[5-chloranyl-4-[(2-chloranyl-4-fluoranyl-phenyl)methylamino]-6-oxidanylidene-pyridazin-1-yl]-1-adamantyl]ethanoic acid | 2-[3-[5-chloro-4-[(2-chloro-4-fluoro-benzyl)amino]-6-keto-pyridazin-1-yl]-1-adamantyl]acetic acid | 2-[3-[5-chloro-4-[(2-chloro-4-fluorophenyl)methylamino]-6-oxo-1-pyridazinyl]-1-adamantyl]acetic acid | 2-[3-[5-chloro-4-[(2-chloro-4-fluorophenyl)methylamino]-6-oxopyridazin-1-yl]-1-adamantyl]acetic acid | MLS000673096 | SMR000314337 | cid_16189389 | {3-[5-chloro-4-[(2-chloro-4-fluorobenzyl)amino]-6-oxopyridazin-1(6H)-yl]-1-adamantyl}acetic acid
Type:
Small organic molecule
Emp. Form.:
C23H24Cl2FN3O3
Mol. Mass.:
480.359
SMILES:
[H]C12CC3([H])CC(CC(O)=O)(C1)CC(C2)(C3)n1ncc(NCc2ccc(F)cc2Cl)c(Cl)c1=O |TLB:15:13:11:3.5.2,16:13:11:3.5.2,THB:15:3:11:13.12.14,2:3:12:1.11.14|
Structure:
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