Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM76014
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists
IC50
7419±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists PubChem Bioassay (2010)[AID] 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM76014
Synonyms:
MLS001220970 | N-(4-Bromo-2,3-dimethyl-phenyl)-2-(6-oxo-3-thiophen-2-yl-6H-pyridazin-1-yl)-acetamide | N-(4-bromanyl-2,3-dimethyl-phenyl)-2-(6-oxidanylidene-3-thiophen-2-yl-pyridazin-1-yl)ethanamide | N-(4-bromo-2,3-dimethyl-phenyl)-2-[6-keto-3-(2-thienyl)pyridazin-1-yl]acetamide | N-(4-bromo-2,3-dimethylphenyl)-2-(6-oxo-3-thiophen-2-yl-1-pyridazinyl)acetamide | N-(4-bromo-2,3-dimethylphenyl)-2-(6-oxo-3-thiophen-2-ylpyridazin-1-yl)acetamide | SMR000606600 | cid_6499077
Type:
Small organic molecule
Emp. Form.:
C18H16BrN3O2S
Mol. Mass.:
418.308
SMILES:
Cc1c(Br)ccc(NC(=O)Cn2nc(ccc2=O)-c2cccs2)c1C
Structure:
Search PDB for entries with ligand similarity: