Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM76015
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists
IC50
2280±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists PubChem Bioassay (2010)[AID] 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM76015
Synonyms:
3-Methoxy-naphthalene-2-carboxylic acid (2-oxo-2H-chromen-6-yl)-amide | 3-methoxy-N-(2-oxidanylidenechromen-6-yl)naphthalene-2-carboxamide | 3-methoxy-N-(2-oxo-1-benzopyran-6-yl)-2-naphthalenecarboxamide | 3-methoxy-N-(2-oxochromen-6-yl)naphthalene-2-carboxamide | MLS001219448 | N-(2-ketochromen-6-yl)-3-methoxy-2-naphthamide | SMR000612701 | cid_965782
Type:
Small organic molecule
Emp. Form.:
C21H15NO4
Mol. Mass.:
345.3481
SMILES:
COc1cc2ccccc2cc1C(=O)Nc1ccc2oc(=O)ccc2c1
Structure:
Search PDB for entries with ligand similarity: