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Target
Intestinal-type alkaline phosphatase 1
Ligand
BDBM53907
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay
IC50
2790±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase 1
Synonyms:
Alpi | PPBI1_RAT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58396.39
Organism:
Rattus norvegicus (Rat)
Description:
P15693
Residue:
540
Sequence:
MQGDWVLLLLLGLRIHLSFGVIPVEEENPVFWNQKAKEALDVAKKLQPIQTSAKNLILFLGDGMGVPTVTATRILKGQLGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQCNSTFGNEVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDWYSDADMPSSALQEGCKDIATQLISNMDIDVILGGGRKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQGTRYVWNREQLMQASQDPAVTRLMGLFEPTEMKYDVNRNASADPSLAEMTEVAVRLLSRNPQGFYLFVEGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIFGLAPLNAQDGKSYTSILYGNGPGYVLNSGNRPNVTDAESGDVNYKQQAAVPLSSETHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQNSAITMNNVLLSLQLLVSMLLLVGTALVVS
  
Inhibitor
Name:
BDBM53907
Synonyms:
2-(5-amino-1,3,4-thiadiazol-2-yl)-N'-{3-bromo-2-hydroxy-5-nitrobenzylidene}acetohydrazide | 2-(5-amino-1,3,4-thiadiazol-2-yl)-N'-[(E)-(5-bromo-3-nitro-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]acetohydrazide | 2-(5-amino-1,3,4-thiadiazol-2-yl)-N'-[(E)-(5-bromo-3-nitro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]acetohydrazide | 2-(5-amino-1,3,4-thiadiazol-2-yl)-N'-[(E)-(5-bromo-6-keto-3-nitro-cyclohexa-2,4-dien-1-ylidene)methyl]acetohydrazide | 2-(5-azanyl-1,3,4-thiadiazol-2-yl)-N'-[(E)-(5-bromanyl-3-nitro-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene)methyl]ethanehydrazide | MLS000705091 | SMR000230750 | cid_16189248
Type:
Small organic molecule
Emp. Form.:
C11H9BrN6O4S
Mol. Mass.:
401.196
SMILES:
Nc1nnc(CC(=O)N\[NH+]=C\[c-]2cc(cc(Br)c2=O)[N+]([O-])=O)s1
Structure:
Search PDB for entries with ligand similarity: