Reaction Details Report a problem with these data
Target
Dual specificity protein phosphatase 3
Ligand
BDBM76335
Substrate
n/a
Meas. Tech.
Dose Response Confirmation of compounds that inhibit VHR1 in Fluorescent Assay
IC50
5690±n/a nM
Citation
 PubChem, PC Dose Response Confirmation of compounds that inhibit VHR1 in Fluorescent Assay PubChem Bioassay (2010)[AID] 
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM76335
Synonyms:
MLS000672558 | N-[4-(difluoromethoxy)phenyl]-6-methyl-2-(4-pyridinyl)-4-quinolinecarboxamide | N-[4-(difluoromethoxy)phenyl]-6-methyl-2-(4-pyridyl)cinchoninamide | N-[4-(difluoromethoxy)phenyl]-6-methyl-2-pyridin-4-yl-4-quinolinecarboxamide | N-[4-(difluoromethoxy)phenyl]-6-methyl-2-pyridin-4-ylquinoline-4-carboxamide | N-[4-[bis(fluoranyl)methoxy]phenyl]-6-methyl-2-pyridin-4-yl-quinoline-4-carboxamide | SMR000295431 | cid_1261372
Type:
Small organic molecule
Emp. Form.:
C23H17F2N3O2
Mol. Mass.:
405.3968
SMILES:
Cc1ccc2nc(cc(C(=O)Nc3ccc(OC(F)F)cc3)c2c1)-c1ccncc1
Structure:
Search PDB for entries with ligand similarity: