Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM51796
Substrate
n/a
Meas. Tech.
Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor
EC50
7440±n/a nM
Citation
 PubChem, PC Dose Response screen for agonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule agonists hits of the APJ receptor PubChem Bioassay (2010)[AID] 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM51796
Synonyms:
(5Z)-5-[(2Z)-2-(3-ethyl-4,5-diphenyl-1,3-thiazol-2-ylidene)ethylidene]-3-methyl-2-sulfanylidene-1,3-thiazolidin-4-one | (5Z)-5-[(2Z)-2-(3-ethyl-4,5-diphenyl-2-thiazolylidene)ethylidene]-3-methyl-2-sulfanylidene-4-thiazolidinone | (5Z)-5-[(2Z)-2-(3-ethyl-4,5-diphenyl-4-thiazolin-2-ylidene)ethylidene]-3-methyl-2-thioxo-thiazolidin-4-one | 5-[2-(3-Ethyl-4,5-diphenyl-3H-thiazol-2-ylidene)-ethylidene]-3-methyl-2-thioxo-thiazolidin-4-one | MLS000526292 | SMR000116766 | cid_1588251
Type:
Small organic molecule
Emp. Form.:
C23H20N2OS3
Mol. Mass.:
436.613
SMILES:
CCN1\C(SC(=C1c1ccccc1)c1ccccc1)=C\C=C1/SC(=S)N(C)C1=O |c:5|
Structure:
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