Reaction Details Report a problem with these data
Target
Intestinal-type alkaline phosphatase
Ligand
BDBM60673
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS activators of Mouse Intestinal Alkaline Phosphatase using Human Intestinal Alkaline Phosphatase
EC50
63000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS activators of Mouse Intestinal Alkaline Phosphatase using Human Intestinal Alkaline Phosphatase PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Alkaline phosphatase, intestinal | Intestinal alkaline phosphatase | PPBI_HUMAN
Type:
PROTEIN
Mol. Mass.:
56804.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1278525
Residue:
528
Sequence:
MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP
  
Inhibitor
Name:
BDBM60673
Synonyms:
2-(1,3-benzoxazol-2-ylsulfanyl)-N'-[(Z)-(3-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]acetohydrazide | 2-(1,3-benzoxazol-2-ylsulfanyl)-N'-[(Z)-(3-oxidanyl-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)methyl]ethanehydrazide | 2-(1,3-benzoxazol-2-ylthio)-N'-[(Z)-(3-hydroxy-4-keto-cyclohexa-2,5-dien-1-ylidene)methyl]acetohydrazide | 2-(1,3-benzoxazol-2-ylthio)-N'-[(Z)-(3-hydroxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]acetohydrazide | MLS000703186 | SMR000273650 | cid_5408334
Type:
Small organic molecule
Emp. Form.:
C16H13N3O4S
Mol. Mass.:
343.357
SMILES:
Oc1ccc(C=NNC(=O)CSc2nc3ccccc3o2)cc1O |w:6.6|
Structure:
Search PDB for entries with ligand similarity: