Reaction Details Report a problem with these data
Target
Intestinal-type alkaline phosphatase 1
Ligand
BDBM75648
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS inhibitors of Human Intestinal Alkaline Phosphatase using Mouse Intestinal Alkaline Phosphatase
IC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS inhibitors of Human Intestinal Alkaline Phosphatase using Mouse Intestinal Alkaline Phosphatase PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase 1
Synonyms:
Alpi | PPBI1_RAT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58396.39
Organism:
Rattus norvegicus (Rat)
Description:
P15693
Residue:
540
Sequence:
MQGDWVLLLLLGLRIHLSFGVIPVEEENPVFWNQKAKEALDVAKKLQPIQTSAKNLILFLGDGMGVPTVTATRILKGQLGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQCNSTFGNEVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDWYSDADMPSSALQEGCKDIATQLISNMDIDVILGGGRKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQGTRYVWNREQLMQASQDPAVTRLMGLFEPTEMKYDVNRNASADPSLAEMTEVAVRLLSRNPQGFYLFVEGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIFGLAPLNAQDGKSYTSILYGNGPGYVLNSGNRPNVTDAESGDVNYKQQAAVPLSSETHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQNSAITMNNVLLSLQLLVSMLLLVGTALVVS
  
Inhibitor
Name:
BDBM75648
Synonyms:
1-N'-[(Z)-(3-ethoxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-2-N'-[(E)-(3-ethoxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]ethanedihydrazide | MLS001164375 | N'~1~,N'~2~-bis(3-ethoxy-4-hydroxybenzylidene)ethanedihydrazide | N1'-[(Z)-(3-ethoxy-4-keto-cyclohexa-2,5-dien-1-ylidene)methyl]-N2'-[(E)-(3-ethoxy-4-keto-cyclohexa-2,5-dien-1-ylidene)methyl]oxalohydrazide | N1'-[(Z)-(3-ethoxy-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)methyl]-N2'-[(E)-(3-ethoxy-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)methyl]ethanedihydrazide | N1'-[(Z)-(3-ethoxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-N2'-[(E)-(3-ethoxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]ethanedihydrazide | SMR000496583 | cid_5334246
Type:
Small organic molecule
Emp. Form.:
C20H22N4O6
Mol. Mass.:
414.4119
SMILES:
CCOc1cc(C=NNC(=O)C(=O)NN=Cc2ccc(O)c(OCC)c2)ccc1O |w:7.7,14.13|
Structure:
Search PDB for entries with ligand similarity: