Reaction Details Report a problem with these data
Target
Intestinal-type alkaline phosphatase 1
Ligand
BDBM58504
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS inhibitors of Human Intestinal Alkaline Phosphatase using Mouse Intestinal Alkaline Phosphatase
IC50
95200±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS inhibitors of Human Intestinal Alkaline Phosphatase using Mouse Intestinal Alkaline Phosphatase PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase 1
Synonyms:
Alpi | PPBI1_RAT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58396.39
Organism:
Rattus norvegicus (Rat)
Description:
P15693
Residue:
540
Sequence:
MQGDWVLLLLLGLRIHLSFGVIPVEEENPVFWNQKAKEALDVAKKLQPIQTSAKNLILFLGDGMGVPTVTATRILKGQLGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQCNSTFGNEVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDWYSDADMPSSALQEGCKDIATQLISNMDIDVILGGGRKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQGTRYVWNREQLMQASQDPAVTRLMGLFEPTEMKYDVNRNASADPSLAEMTEVAVRLLSRNPQGFYLFVEGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIFGLAPLNAQDGKSYTSILYGNGPGYVLNSGNRPNVTDAESGDVNYKQQAAVPLSSETHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQNSAITMNNVLLSLQLLVSMLLLVGTALVVS
  
Inhibitor
Name:
BDBM58504
Synonyms:
1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-N'-[(Z)-(2-oxo-1-naphthalenylidene)methyl]-4-triazolecarbohydrazide | 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-N'-[(Z)-(2-oxonaphthalen-1-ylidene)methyl]triazole-4-carbohydrazide | 1-(4-aminofurazan-3-yl)-N'-[(Z)-(2-keto-1-naphthylidene)methyl]-5-methyl-triazole-4-carbohydrazide | 1-(4-azanyl-1,2,5-oxadiazol-3-yl)-5-methyl-N'-[(Z)-(2-oxidanylidenenaphthalen-1-ylidene)methyl]-1,2,3-triazole-4-carbohydrazide | MLS000950073 | SMR000619782 | cid_24789706
Type:
Small organic molecule
Emp. Form.:
C17H14N8O3
Mol. Mass.:
378.3449
SMILES:
Cc1c(nnn1-c1nonc1N)C(=O)NN=Cc1c(O)ccc2ccccc12 |w:15.16|
Structure:
Search PDB for entries with ligand similarity: