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Target
Intestinal-type alkaline phosphatase 1
Ligand
BDBM75705
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS inhibitors of Human Intestinal Alkaline Phosphatase using Mouse Intestinal Alkaline Phosphatase
IC50
74800±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS inhibitors of Human Intestinal Alkaline Phosphatase using Mouse Intestinal Alkaline Phosphatase PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase 1
Synonyms:
Alpi | PPBI1_RAT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58396.39
Organism:
Rattus norvegicus (Rat)
Description:
P15693
Residue:
540
Sequence:
MQGDWVLLLLLGLRIHLSFGVIPVEEENPVFWNQKAKEALDVAKKLQPIQTSAKNLILFLGDGMGVPTVTATRILKGQLGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQCNSTFGNEVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDWYSDADMPSSALQEGCKDIATQLISNMDIDVILGGGRKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQGTRYVWNREQLMQASQDPAVTRLMGLFEPTEMKYDVNRNASADPSLAEMTEVAVRLLSRNPQGFYLFVEGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIFGLAPLNAQDGKSYTSILYGNGPGYVLNSGNRPNVTDAESGDVNYKQQAAVPLSSETHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQNSAITMNNVLLSLQLLVSMLLLVGTALVVS
  
Inhibitor
Name:
BDBM75705
Synonyms:
5-N-benzyl-5-N-methyl-4-N-(1,3-thiazol-2-yl)-1H-imidazole-4,5-dicarboxamide | MLS002391311 | N'-benzyl-N'-methyl-N-thiazol-2-yl-1H-imidazole-4,5-dicarboxamide | N5-methyl-N5-(phenylmethyl)-N4-(1,3-thiazol-2-yl)-1H-imidazole-4,5-dicarboxamide | N5-methyl-N5-(phenylmethyl)-N4-(2-thiazolyl)-1H-imidazole-4,5-dicarboxamide | SMR001355310 | cid_44142711
Type:
Small organic molecule
Emp. Form.:
C16H15N5O2S
Mol. Mass.:
341.388
SMILES:
CN(Cc1ccccc1)C(=O)c1nc[nH]c1C(=O)Nc1nccs1
Structure:
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