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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM40697
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS activators of Mouse Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase.
EC50
70900±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS activators of Mouse Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase. PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM40697
Synonyms:
4-(2,3-dihydroimidazo[2,1-b][1,3]thiazol-6-yl)-1,2-benzenediol | 4-(2,3-dihydroimidazo[2,1-b][1,3]thiazol-6-yl)benzene-1,2-diol | 4-(2,3-dihydroimidazo[2,1-b]thiazol-6-yl)benzene-1,2-diol | 4-(2,3-dihydroimidazo[2,1-b]thiazol-6-yl)pyrocatechol | MLS000530540 | SMR000135520 | cid_877570
Type:
Small organic molecule
Emp. Form.:
C11H10N2O2S
Mol. Mass.:
234.274
SMILES:
Oc1ccc(cc1O)-c1cn2CCSc2n1
Structure:
Search PDB for entries with ligand similarity: