Reaction Details Report a problem with these data
Target
Alkaline phosphatase, germ cell type
Ligand
BDBM75688
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase
EC50
15300±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, germ cell type
Synonyms:
ALPG | ALPPL | ALPPL2 | Alkaline phosphatase placental-like | PPBN_HUMAN | placental-like alkaline phosphatase preproprotein
Type:
PROTEIN
Mol. Mass.:
57374.31
Organism:
Homo sapiens (Human)
Description:
ChEMBL_29964
Residue:
532
Sequence:
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP
  
Inhibitor
Name:
BDBM75688
Synonyms:
1-(4-methylphenyl)-3-[(3-oxidanylnaphthalen-2-yl)carbonylamino]urea | 1-[(3-hydroxy-2-naphthoyl)amino]-3-(p-tolyl)urea | 1-[(3-hydroxynaphthalene-2-carbonyl)amino]-3-(4-methylphenyl)urea | 1-[[(3-hydroxy-2-naphthalenyl)-oxomethyl]amino]-3-(4-methylphenyl)urea | MLS001232556 | SMR000679181 | cid_24820057
Type:
Small organic molecule
Emp. Form.:
C19H17N3O3
Mol. Mass.:
335.3566
SMILES:
Cc1ccc(NC(=O)NNC(=O)c2cc3ccccc3cc2O)cc1
Structure:
Search PDB for entries with ligand similarity: