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Target
Sentrin-specific protease 8
Ligand
BDBM48245
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Luminescent Interference Counterscreen assay
IC50
458±14 nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Luminescent Interference Counterscreen assay PubChem Bioassay (2010)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM48245
Synonyms:
(E)-3-(2-methoxy-4-nitro-anilino)-1-(2-thienyl)prop-2-en-1-one | (E)-3-(2-methoxy-4-nitroanilino)-1-thiophen-2-yl-2-propen-1-one | (E)-3-(2-methoxy-4-nitroanilino)-1-thiophen-2-ylprop-2-en-1-one | (E)-3-[(2-methoxy-4-nitro-phenyl)amino]-1-thiophen-2-yl-prop-2-en-1-one | 3-[(2-methoxy-4-nitrophenyl)amino]-1-(2-thienyl)-2-propen-1-one | MLS000537797 | SMR000144035 | cid_5739690
Type:
Small organic molecule
Emp. Form.:
C14H12N2O4S
Mol. Mass.:
304.321
SMILES:
COc1cc(ccc1N=CCC(=O)c1cccs1)[N+]([O-])=O |w:8.8|
Structure:
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