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Target
Sentrin-specific protease 8
Ligand
BDBM52448
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Luminescent Interference Counterscreen assay
IC50
888±46 nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Luminescent Interference Counterscreen assay PubChem Bioassay (2010)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM52448
Synonyms:
(3E)-1H-indole-2,3-dione 3-[(4-fluorophenyl)hydrazone] | 3-[(4-fluorophenyl)hydrazo]-2-indolone | 3-[2-(4-fluorophenyl)hydrazinyl]indol-2-one | 3-[N'-(4-fluorophenyl)hydrazino]indol-2-one | MLS000586494 | SMR000207873 | cid_6287295
Type:
Small organic molecule
Emp. Form.:
C14H10FN3O
Mol. Mass.:
255.2471
SMILES:
Fc1ccc(NNC2=c3ccccc3=NC2=O)cc1 |c:7,14|
Structure:
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