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Target
Sentrin-specific protease 8
Ligand
BDBM76632
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Luminescent Interference Counterscreen assay
IC50
865±47 nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Luminescent Interference Counterscreen assay PubChem Bioassay (2010)[AID] 
Target
Name:
Sentrin-specific protease 8
Synonyms:
DEN1 | NEDP1 | PRSC2 | SENP8 | SENP8_HUMAN | SUMO/sentrin specific peptidase family member 8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24104.52
Organism:
Homo sapiens (Human)
Description:
gi_262118306
Residue:
212
Sequence:
MDPVVLSYMDSLLRQSDVSLLDPPSWLNDHIIGFAFEYFANSQFHDCSDHVSFISPEVTQFIKCTSNPAEIAMFLEPLDLPNKRVVFLAINDNSNQAAGGTHWSLLVYLQDKNSFFHYDSHSRSNSVHAKQVAEKLEAFLGRKGDKLAFVEEKAPAQQNSYDCGMYVICNTEALCQNFFRQQTESLLQLLTPAYITKKRGEWKDLITTLAKK
  
Inhibitor
Name:
BDBM76632
Synonyms:
(4,6-dimethylpyrimidin-2-yl)-(4-phenylthiazol-2-yl)amine | MLS001183973 | N-(4,6-dimethyl-2-pyrimidinyl)-4-phenyl-2-thiazolamine | N-(4,6-dimethylpyrimidin-2-yl)-4-phenyl-1,3-thiazol-2-amine | SMR000502662 | cid_2354999
Type:
Small organic molecule
Emp. Form.:
C15H14N4S
Mol. Mass.:
282.363
SMILES:
Cc1cc(C)nc(Nc2nc(cs2)-c2ccccc2)n1
Structure:
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