Reaction Details Report a problem with these data
Target
Caspase-3
Ligand
BDBM77506
Substrate
n/a
Meas. Tech.
Absorbance-based biochemical high throughput dose response assay for activators of procaspase-3
EC50
13439±n/a nM
Citation
 PubChem, PC Absorbance-based biochemical high throughput dose response assay for activators of procaspase-3 PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM77506
Synonyms:
2-keto-6-nitro-N-[1-(tetrahydrofuryl)ethyl]chromene-3-carboxamide | 6-nitro-2-oxidanylidene-N-[1-(oxolan-2-yl)ethyl]chromene-3-carboxamide | 6-nitro-2-oxo-N-[1-(2-oxolanyl)ethyl]-1-benzopyran-3-carboxamide | 6-nitro-2-oxo-N-[1-(oxolan-2-yl)ethyl]chromene-3-carboxamide | 6-nitro-2-oxo-N-[1-(tetrahydro-2-furanyl)ethyl]-2H-chromene-3-carboxamide | MLS000684331 | SMR000295896 | cid_2970929
Type:
Small organic molecule
Emp. Form.:
C16H16N2O6
Mol. Mass.:
332.308
SMILES:
CC(NC(=O)c1cc2cc(ccc2oc1=O)[N+]([O-])=O)C1CCCO1
Structure:
Search PDB for entries with ligand similarity: