Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM78074
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay
IC50
250±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM78074
Synonyms:
2-naphthalenecarboxylic acid [(Z)-[1-amino-2-(4-chlorophenyl)ethylidene]amino] ester | MLS000556016 | SMR000147533 | [(Z)-[1-amino-2-(4-chlorophenyl)ethylidene]amino] naphthalene-2-carboxylate | [(Z)-[1-azanyl-2-(4-chlorophenyl)ethylidene]amino] naphthalene-2-carboxylate | cid_9550597 | naphthalene-2-carboxylic acid [(Z)-[1-amino-2-(4-chlorophenyl)ethylidene]amino] ester
Type:
Small organic molecule
Emp. Form.:
C19H15ClN2O2
Mol. Mass.:
338.788
SMILES:
NC(Cc1ccc(Cl)cc1)=NOC(=O)c1ccc2ccccc2c1 |w:10.11|
Structure:
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