Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM61610
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay
IC50
5770±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM61610
Synonyms:
(2-Methyl-[1,3]dioxan-2-yl)-acetic acid [4-(2,4-dichloro-benzyloxy)-benzylidene]-hydrazide | MLS000563840 | N-[[4-(2,4-dichlorobenzyl)oxybenzylidene]amino]-2-(2-methyl-1,3-dioxan-2-yl)acetamide | N-[[4-[(2,4-dichlorophenyl)methoxy]phenyl]methylideneamino]-2-(2-methyl-1,3-dioxan-2-yl)acetamide | N-[[4-[(2,4-dichlorophenyl)methoxy]phenyl]methylideneamino]-2-(2-methyl-1,3-dioxan-2-yl)ethanamide | SMR000175638 | cid_1087298
Type:
Small organic molecule
Emp. Form.:
C21H22Cl2N2O4
Mol. Mass.:
437.316
SMILES:
CC1(CC(=O)NN=Cc2ccc(OCc3ccc(Cl)cc3Cl)cc2)OCCCO1
Structure:
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