Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM78208
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay
IC50
9340±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM78208
Synonyms:
1,3-benzodioxole-5-carboxylic acid [(Z)-[amino-(4-methylphenyl)methylidene]amino] ester | MLS000588449 | SMR000219889 | [(Z)-[amino-(4-methylphenyl)methylidene]amino] 1,3-benzodioxole-5-carboxylate | [(Z)-[azanyl-(4-methylphenyl)methylidene]amino] 1,3-benzodioxole-5-carboxylate | cid_9637093 | piperonylic acid [(Z)-[amino(p-tolyl)methylene]amino] ester
Type:
Small organic molecule
Emp. Form.:
C16H14N2O4
Mol. Mass.:
298.2934
SMILES:
Cc1ccc(cc1)C(N)=NOC(=O)c1ccc2OCOc2c1 |w:9.10|
Structure:
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