Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM75100
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay
IC50
8410±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM75100
Synonyms:
2-Amino-1-(3-morpholin-4-yl-propyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxylic acid phenylamide | 2-amino-1-(3-morpholin-4-ylpropyl)-N-phenylpyrrolo[3,2-b]quinoxaline-3-carboxamide | 2-amino-1-(3-morpholinopropyl)-N-phenyl-pyrrolo[3,2-b]quinoxaline-3-carboxamide | 2-amino-1-[3-(4-morpholinyl)propyl]-N-phenyl-3-pyrrolo[3,2-b]quinoxalinecarboxamide | 2-azanyl-1-(3-morpholin-4-ylpropyl)-N-phenyl-pyrrolo[3,2-b]quinoxaline-3-carboxamide | MLS000333090 | SMR000436501 | cid_2026916
Type:
Small organic molecule
Emp. Form.:
C24H26N6O2
Mol. Mass.:
430.5022
SMILES:
Nc1c(C(=O)Nc2ccccc2)c2nc3ccccc3nc2n1CCCN1CCOCC1
Structure:
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