Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM50056
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
17100±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM50056
Synonyms:
2-ethoxy-5-hydroxy-1H-benz[g]indole-3-carboxylic acid ethyl ester | 2-ethoxy-5-hydroxy-1H-benzo[g]indole-3-carboxylic acid ethyl ester | MLS000106842 | SMR000111218 | cid_784748 | ethyl 2-ethoxy-5-hydroxy-1H-benzo[g]indole-3-carboxylate | ethyl 2-ethoxy-5-oxidanyl-1H-benzo[g]indole-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C17H17NO4
Mol. Mass.:
299.3212
SMILES:
CCOC(=O)c1c(OCC)[nH]c2c1cc(O)c1ccccc21
Structure:
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