Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78087
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
9860±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78087
Synonyms:
2-[4-(4-methylphenyl)sulfonylimino-1-oxo-2-naphthalenyl]-3-oxobutanoic acid methyl ester | 3-keto-2-(1-keto-4-tosylimino-2-naphthyl)butyric acid methyl ester | MLS000521425 | SMR000131833 | cid_9551443 | methyl 2-[4-(4-methylphenyl)sulfonylimino-1-oxidanylidene-naphthalen-2-yl]-3-oxidanylidene-butanoate | methyl 2-[4-(4-methylphenyl)sulfonylimino-1-oxonaphthalen-2-yl]-3-oxobutanoate
Type:
Small organic molecule
Emp. Form.:
C22H19NO6S
Mol. Mass.:
425.454
SMILES:
COC(=O)C(C(C)=O)=C1C=C(NS(=O)(=O)c2ccc(C)cc2)c2ccccc2C1=O |w:8.30,t:9|
Structure:
Search PDB for entries with ligand similarity: