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Target
Neurotensin receptor type 1
Ligand
BDBM72121
Substrate
n/a
Meas. Tech.
Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1
EC50
33900±n/a nM
Citation
 PubChem, PC Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1 PubChem Bioassay (2011)[AID] 
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
  
Inhibitor
Name:
BDBM72121
Synonyms:
2-[(1,3-diphenyl-1H-pyrazol-4-yl)methylene]-5,5-dimethyl-1,3-cyclohexanedione | 2-[(1,3-diphenyl-4-pyrazolyl)methylidene]-5,5-dimethylcyclohexane-1,3-dione | 2-[(1,3-diphenylpyrazol-4-yl)methylene]-5,5-dimethyl-cyclohexane-1,3-quinone | 2-[(1,3-diphenylpyrazol-4-yl)methylidene]-5,5-dimethyl-cyclohexane-1,3-dione | 2-[(1,3-diphenylpyrazol-4-yl)methylidene]-5,5-dimethylcyclohexane-1,3-dione | MLS000578647 | SMR000186140 | cid_1181160
Type:
Small organic molecule
Emp. Form.:
C24H22N2O2
Mol. Mass.:
370.4437
SMILES:
[#6]C1([#6])[#6]-[#6](=O)\[#6](=[#6]/c2cn(nc2-c2ccccc2)-c2ccccc2)-[#6](=O)-[#6]1
Structure:
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