Reaction Details Report a problem with these data
Target
Neurotensin receptor type 1
Ligand
BDBM79548
Substrate
n/a
Meas. Tech.
Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1
EC50
16500±n/a nM
Citation
 PubChem, PC Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1 PubChem Bioassay (2011)[AID] 
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
  
Inhibitor
Name:
BDBM79548
Synonyms:
6-amino-5-[2-(2,5-dichlorophenyl)sulfanylacetyl]-3-methyl-1-(2-methylpropyl)pyrimidine-2,4-dione | 6-amino-5-[2-[(2,5-dichlorophenyl)thio]-1-oxoethyl]-3-methyl-1-(2-methylpropyl)pyrimidine-2,4-dione | 6-amino-5-[2-[(2,5-dichlorophenyl)thio]acetyl]-1-isobutyl-3-methyl-pyrimidine-2,4-quinone | 6-azanyl-5-[2-[2,5-bis(chloranyl)phenyl]sulfanylethanoyl]-3-methyl-1-(2-methylpropyl)pyrimidine-2,4-dione | MLS000334989 | SMR000249747 | cid_2092791
Type:
Small organic molecule
Emp. Form.:
C17H19Cl2N3O3S
Mol. Mass.:
416.322
SMILES:
CC(C)Cn1c(N)c(C(=O)CSc2cc(Cl)ccc2Cl)c(=O)n(C)c1=O
Structure:
Search PDB for entries with ligand similarity: