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Target
Neurotensin receptor type 1
Ligand
BDBM79574
Substrate
n/a
Meas. Tech.
Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1
EC50
17600±n/a nM
Citation
 PubChem, PC Dose Response confirmation of Image-Based HTS for Selective Agonists for NTR1 PubChem Bioassay (2011)[AID] 
Target
Name:
Neurotensin receptor type 1
Synonyms:
Dopamine receptor D2L/neurotensin receptor NTS1 | NTR1_HUMAN | NTRR | NTSR1 | Neurotensin receptor 1 | neurotensin receptor type 1
Type:
PROTEIN
Mol. Mass.:
46278.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1453811
Residue:
418
Sequence:
MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRHGVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTINPILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY
  
Inhibitor
Name:
BDBM79574
Synonyms:
4-(2-{N'-[1-(4-Hydroxy-3-methoxy-phenyl)-meth-(Z)-ylidene]-hydrazino}-thiazol-4-yl)-N,N-dimethyl-benze nesulfonamide | 4-[2-[2-[(E)-(3-methoxy-4-oxidanylidene-cyclohexa-2,5-dien-1-ylidene)methyl]hydrazinyl]-1,3-thiazol-4-yl]-N,N-dimethyl-benzenesulfonamide | 4-[2-[2-[(E)-(3-methoxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]hydrazinyl]-1,3-thiazol-4-yl]-N,N-dimethylbenzenesulfonamide | 4-[2-[N'-[(E)-(4-keto-3-methoxy-cyclohexa-2,5-dien-1-ylidene)methyl]hydrazino]thiazol-4-yl]-N,N-dimethyl-benzenesulfonamide | 4-[2-[[(E)-(3-methoxy-4-oxo-1-cyclohexa-2,5-dienylidene)methyl]hydrazo]-4-thiazolyl]-N,N-dimethylbenzenesulfonamide | MLS000778018 | SMR000414412 | cid_5929130
Type:
Small organic molecule
Emp. Form.:
C19H20N4O4S2
Mol. Mass.:
432.516
SMILES:
COc1cc(CN=Nc2nc(cs2)-c2ccc(cc2)S(=O)(=O)N(C)C)ccc1O |w:7.7|
Structure:
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