Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM37183
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen.
IC50
10100±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim23-1: a luminescent TIM10 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM37183
Synonyms:
3-(4-hydroxyphenyl)-5-oxidanyl-7-propan-2-yloxy-chromen-4-one | 5-hydroxy-3-(4-hydroxyphenyl)-7-isopropoxy-chromone | 5-hydroxy-3-(4-hydroxyphenyl)-7-propan-2-yloxy-1-benzopyran-4-one | 5-hydroxy-3-(4-hydroxyphenyl)-7-propan-2-yloxychromen-4-one | MLS000115520 | SMR000092610 | cid_5308744
Type:
Small organic molecule
Emp. Form.:
C18H16O5
Mol. Mass.:
312.3166
SMILES:
CC(C)Oc1cc(O)c2c(c1)occ(-c1ccc(O)cc1)c2=O
Structure:
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