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Target
Tropomyosin alpha-1 chain
Ligand
BDBM79675
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)
EC50
>71492±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) PubChem Bioassay (2011)[AID] 
Target
Name:
Tropomyosin alpha-1 chain
Synonyms:
TPM1 | TPM1_PIG | cardiac alpha tropomyosin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32681.01
Organism:
Sus scrofa
Description:
P42639
Residue:
284
Sequence:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKYSEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
  
Inhibitor
Name:
BDBM79675
Synonyms:
(E)-2-Cyano-N-[5-(2,4-dichloro-benzyl)-thiazol-2-yl]-3-(1H-indol-3-yl)-acrylamide | (E)-2-cyano-N-[5-(2,4-dichlorobenzyl)thiazol-2-yl]-3-(1H-indol-3-yl)acrylamide | (E)-2-cyano-N-[5-[(2,4-dichlorophenyl)methyl]-1,3-thiazol-2-yl]-3-(1H-indol-3-yl)prop-2-enamide | (E)-2-cyano-N-[5-[(2,4-dichlorophenyl)methyl]-2-thiazolyl]-3-(1H-indol-3-yl)-2-propenamide | MLS000591042 | SMR000217836 | cid_1387465
Type:
Small organic molecule
Emp. Form.:
C22H14Cl2N4OS
Mol. Mass.:
453.344
SMILES:
Clc1ccc(Cc2cnc(NC(=O)C(=C\c3c[nH]c4ccccc34)\C#N)s2)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: