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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM79910
Substrate
n/a
Meas. Tech.
Fluorescence-based cell-based high throughput dose response assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1)
IC50
1335±n/a nM
Citation
 PubChem, PC Fluorescence-based cell-based high throughput dose response assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1) PubChem Bioassay (2011)[AID] 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM79910
Synonyms:
MLS001205953 | N-(3,4-Dimethoxy-phenyl)-N'-quinolin-8-yl-oxalamide | N-(3,4-dimethoxyphenyl)-N'-(8-quinolinyl)oxamide | N-(3,4-dimethoxyphenyl)-N'-(8-quinolyl)oxamide | N-(3,4-dimethoxyphenyl)-N'-quinolin-8-yl-ethanediamide | N-(3,4-dimethoxyphenyl)-N'-quinolin-8-yloxamide | SMR000504655 | cid_24746898
Type:
Small organic molecule
Emp. Form.:
C19H17N3O4
Mol. Mass.:
351.356
SMILES:
COc1ccc(NC(=O)C(=O)Nc2cccc3cccnc23)cc1OC
Structure:
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