Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM77703
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
936±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM77703
Synonyms:
3-(3-chloranyl-1-benzothiophen-2-yl)-4-methyl-1H-1,2,4-triazole-5-thione | 3-(3-chloro-1-benzothiophen-2-yl)-4-methyl-1H-1,2,4-triazole-5-thione | 3-(3-chlorobenzothiophen-2-yl)-4-methyl-1H-1,2,4-triazole-5-thione | MLS000564249 | SMR000151790 | cid_694414
Type:
Small organic molecule
Emp. Form.:
C11H8ClN3S2
Mol. Mass.:
281.784
SMILES:
Cn1c(n[nH]c1=S)-c1sc2ccccc2c1Cl
Structure:
