Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM80096
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3G DNA Deaminase Inhibitors via a A3A counterscreen
Temperature
298.15±n/a K
IC50
61200±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of APOBEC3G DNA Deaminase Inhibitors via a A3A counterscreen PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM80096
Synonyms:
MLS000033673 | N,N-Diethyl-2-(3-thiophen-2-yl-isothiazolo[4,5-d]pyrimidin-7-ylsulfanyl)-acetamide | N,N-diethyl-2-[(3-thiophen-2-yl-7-isothiazolo[4,5-d]pyrimidinyl)thio]acetamide | N,N-diethyl-2-[(3-thiophen-2-yl-[1,2]thiazolo[4,5-d]pyrimidin-7-yl)sulfanyl]acetamide | N,N-diethyl-2-[(3-thiophen-2-yl-[1,2]thiazolo[4,5-d]pyrimidin-7-yl)sulfanyl]ethanamide | N,N-diethyl-2-[[3-(2-thienyl)isothiazolo[4,5-d]pyrimidin-7-yl]thio]acetamide | SMR000005541 | cid_653996
Type:
Small organic molecule
Emp. Form.:
C15H16N4OS3
Mol. Mass.:
364.509
SMILES:
CCN(CC)C(=O)CSc1ncnc2c(nsc12)-c1cccs1
Structure:
