Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM34452
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3G DNA Deaminase Inhibitors via a A3A counterscreen
Temperature
298.15±n/a K
IC50
>100000±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of APOBEC3G DNA Deaminase Inhibitors via a A3A counterscreen PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM34452
Synonyms:
(4-amino-3-phenyl-2-sulfanylidene-1,3-thiazol-5-yl)-(4-methylpiperazin-1-yl)methanone | (4-amino-3-phenyl-2-sulfanylidene-5-thiazolyl)-(4-methyl-1-piperazinyl)methanone | (4-amino-3-phenyl-2-thioxo-4-thiazolin-5-yl)-(4-methylpiperazino)methanone | (4-azanyl-3-phenyl-2-sulfanylidene-1,3-thiazol-5-yl)-(4-methylpiperazin-1-yl)methanone | 4-amino-5-[(4-methyl-1-piperazinyl)carbonyl]-3-phenyl-1,3-thiazole-2(3H)-thione | MLS000088091 | SMR000072313 | cid_889170
Type:
Small organic molecule
Emp. Form.:
C15H18N4OS2
Mol. Mass.:
334.46
SMILES:
CN1CCN(CC1)C(=O)c1sc(=S)n(c1N)-c1ccccc1
Structure:
