Reaction Details
Report a problem with these data
Report a problem with these dataTarget
DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM80217
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3G DNA Deaminase Inhibitors via a A3A counterscreen
Temperature
298.15±n/a K
IC50
>100000±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of APOBEC3G DNA Deaminase Inhibitors via a A3A counterscreen PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM80217
Synonyms:
4-[(3,5-dimethyl-1-phenyl-4-pyrazolyl)methylideneamino]-3-pyridin-4-yl-1H-1,2,4-triazole-5-thione | 4-[(3,5-dimethyl-1-phenyl-pyrazol-4-yl)methyleneamino]-3-(4-pyridyl)-1H-1,2,4-triazole-5-thione | 4-[(3,5-dimethyl-1-phenyl-pyrazol-4-yl)methylideneamino]-3-pyridin-4-yl-1H-1,2,4-triazole-5-thione | 4-[(3,5-dimethyl-1-phenylpyrazol-4-yl)methylideneamino]-3-pyridin-4-yl-1H-1,2,4-triazole-5-thione | 4-{[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]amino}-5-(4-pyridinyl)-4H-1,2,4-triazole-3-thiol | MLS000677596 | SMR000271759 | cid_1290540
Type:
Small organic molecule
Emp. Form.:
C19H17N7S
Mol. Mass.:
375.45
SMILES:
Cc1nn(c(C)c1C=Nn1c(n[nH]c1=S)-c1ccncc1)-c1ccccc1 |w:8.9|
Structure:
