Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM80542
Substrate
n/a
Meas. Tech.
Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen
Temperature
298.15±n/a K
IC50
1920±124 nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of APOBEC3A DNA Deaminase Inhibitors via a A3G counterscreen PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM80542
Synonyms:
1-Methyl-2-((E)-2-quinolin-6-yl-vinyl)-pyridinium | 6-[(E)-2-(1-methyl-2-pyridin-1-iumyl)ethenyl]quinoline;iodide | 6-[(E)-2-(1-methylpyridin-1-ium-2-yl)ethenyl]quinoline;iodide | 6-[(E)-2-(1-methylpyridin-1-ium-2-yl)vinyl]quinoline;iodide | MLS001208265 | SMR000504367 | cid_24746842
Type:
Small organic molecule
Emp. Form.:
C17H15N2
Mol. Mass.:
247.3139
SMILES:
C[n+]1ccccc1\C=C\c1ccc2ncccc2c1
Structure:
