Reaction Details Report a problem with these data
Target
Cysteine protease ATG4B
Ligand
BDBM80987
Substrate
n/a
Meas. Tech.
Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B.
IC50
2020±n/a nM
Citation
 PubChem, PC Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B. PubChem Bioassay (2011)[AID] 
Target
Name:
Cysteine protease ATG4B
Synonyms:
APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44279.79
Organism:
Homo sapiens (Human)
Description:
gi_47132611
Residue:
393
Sequence:
MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLACPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
  
Inhibitor
Name:
BDBM80987
Synonyms:
2-chloranyl-3-(4-methylpiperazin-1-yl)naphthalene-1,4-dione | 2-chloro-3-(4-methyl-1-piperazinyl)naphthalene-1,4-dione | 2-chloro-3-(4-methylpiperazin-1-yl)naphthalene-1,4-dione | 2-chloro-3-(4-methylpiperazino)-1,4-naphthoquinone | MLS002608219 | SMR001526970 | cid_237102
Type:
Small organic molecule
Emp. Form.:
C15H15ClN2O2
Mol. Mass.:
290.745
SMILES:
CN1CCN(CC1)C1=C(Cl)C(=O)c2ccccc2C1=O |c:8|
Structure:
Search PDB for entries with ligand similarity: