Reaction Details Report a problem with these data
Target
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Ligand
BDBM82658
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay
IC50
1718±94 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay PubChem Bioassay (2011)[AID] 
Target
Name:
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Synonyms:
CTDS1_HUMAN | CTDSP1 | NIF3 | NLIIF | SCP1 | carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29199.89
Organism:
Homo sapiens (Human)
Description:
gi_10864009
Residue:
261
Sequence:
MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
  
Inhibitor
Name:
BDBM82658
Synonyms:
MLS000546098 | N'-(3-phenyl-2-propenylidene)naphtho[2,1-b]furan-2-carbohydrazide | N-[[(E)-3-phenylprop-2-enylidene]amino]-2-benzo[e]benzofurancarboxamide | N-[[(E)-3-phenylprop-2-enylidene]amino]benzo[e][1]benzofuran-2-carboxamide | N-[[(E)-3-phenylprop-2-enylidene]amino]benzo[e]benzofuran-2-carboxamide | SMR000161102 | cid_1807044
Type:
Small organic molecule
Emp. Form.:
C22H16N2O2
Mol. Mass.:
340.3746
SMILES:
O=C(NN=C\C=C\c1ccccc1)c1cc2c(ccc3ccccc23)o1
Structure:
Search PDB for entries with ligand similarity: