Reaction Details Report a problem with these data
Target
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Ligand
BDBM51077
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay
IC50
1857±224 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay PubChem Bioassay (2011)[AID] 
Target
Name:
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Synonyms:
CTDS1_HUMAN | CTDSP1 | NIF3 | NLIIF | SCP1 | carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29199.89
Organism:
Homo sapiens (Human)
Description:
gi_10864009
Residue:
261
Sequence:
MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
  
Inhibitor
Name:
BDBM51077
Synonyms:
(5Z)-4-(4-chloroanilino)-5-(2-furanylmethylidene)-2-thiazolone | (5Z)-4-(4-chloroanilino)-5-(2-furfurylidene)-3-thiazolin-2-one | (5Z)-4-(4-chloroanilino)-5-(furan-2-ylmethylidene)-1,3-thiazol-2-one | (5Z)-4-[(4-chlorophenyl)amino]-5-(furan-2-ylmethylidene)-1,3-thiazol-2-one | MLS000724782 | SMR000236935 | cid_2146880
Type:
Small organic molecule
Emp. Form.:
C14H9ClN2O2S
Mol. Mass.:
304.751
SMILES:
Clc1ccc(NC2=NC(=O)SC2=Cc2ccco2)cc1 |w:12.13,t:6|
Structure:
Search PDB for entries with ligand similarity: