Reaction Details Report a problem with these data
Target
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Ligand
BDBM82792
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay
IC50
1779±75 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay PubChem Bioassay (2011)[AID] 
Target
Name:
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Synonyms:
CTDS1_HUMAN | CTDSP1 | NIF3 | NLIIF | SCP1 | carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29199.89
Organism:
Homo sapiens (Human)
Description:
gi_10864009
Residue:
261
Sequence:
MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
  
Inhibitor
Name:
BDBM82792
Synonyms:
2-[4-[(Z)-2-(2,4-diketo-5-nitro-1H-pyrimidin-6-yl)vinyl]phenoxy]-N-(m-tolyl)acetamide | MLS000690435 | N-(3-methylphenyl)-2-[4-[(Z)-2-(5-nitro-2,4-dioxo-1H-pyrimidin-6-yl)ethenyl]phenoxy]acetamide | N-(3-methylphenyl)-2-[4-[(Z)-2-[5-nitro-2,4-bis(oxidanylidene)-1H-pyrimidin-6-yl]ethenyl]phenoxy]ethanamide | N-(3-methylphenyl)-2-{4-[2-(5-nitro-2,6-dioxo-1,2,3,6-tetrahydro-4-pyrimidinyl)vinyl]phenoxy}acetamide | SMR000300238 | cid_5739979
Type:
Small organic molecule
Emp. Form.:
C21H18N4O6
Mol. Mass.:
422.3908
SMILES:
Cc1cccc(NC(=O)COc2ccc(C=Cc3[nH]c(=O)[nH]c(=O)c3[N+]([O-])=O)cc2)c1 |w:16.16|
Structure:
Search PDB for entries with ligand similarity: