Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM57514
Substrate
n/a
Meas. Tech.
Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay
IC50
2300±n/a nM
Citation
 PubChem, PC Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay PubChem Bioassay (2011)[AID] 
Target
Name:
Phospholipase A2
Synonyms:
Group IB phospholipase A2 | PA21B_HUMAN | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | phospholipase A2 precursor
Type:
Protein
Mol. Mass.:
16364.13
Organism:
Homo sapiens (Human)
Description:
P04054
Residue:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
  
Inhibitor
Name:
BDBM57514
Synonyms:
(6E)-5-azanylidene-6-[[1-(3,5-dimethylphenyl)-2,5-dimethyl-pyrrol-3-yl]methylidene]-2-(2-methylpropyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one | (6E)-6-[[1-(3,5-dimethylphenyl)-2,5-dimethyl-3-pyrrolyl]methylidene]-5-imino-2-(2-methylpropyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one | (6E)-6-[[1-(3,5-dimethylphenyl)-2,5-dimethyl-pyrrol-3-yl]methylene]-5-imino-2-isobutyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one | (6E)-6-[[1-(3,5-dimethylphenyl)-2,5-dimethylpyrrol-3-yl]methylidene]-5-imino-2-(2-methylpropyl)-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one | 6-[1-[1-(3,5-Dimethyl-phenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-meth-(E)-ylidene]-5-imino-2-isobutyl-5,6-dihydro-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one | MLS000331399 | SMR000220865 | cid_12004624
Type:
Small organic molecule
Emp. Form.:
C24H27N5OS
Mol. Mass.:
433.569
SMILES:
CC(C)CC1=NN2C(S1)=NC(=O)\C(=C\c1cc(C)n(c1C)-c1cc(C)cc(C)c1)C2=N |c:9,t:4|
Structure:
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