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Target
Delta-type opioid receptor
Ligand
BDBM83447
Substrate
n/a
Meas. Tech.
Counterscreen for agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors: Luminescence-based cell-based high throughput dose response assay
EC50
11928±n/a nM
Citation
 PubChem, PC Counterscreen for agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors: Luminescence-based cell-based high throughput dose response assay to identify agonists of OPRD1 homodimerization PubChem Bioassay (2011)[AID] 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM83447
Synonyms:
4-(4-bromo-2,6-dichloro-phenyl)sulfonyl-N-cyclopropyl-piperazine-1-carbothioamide | 4-(4-bromo-2,6-dichlorophenyl)sulfonyl-N-cyclopropyl-1-piperazinecarbothioamide | 4-(4-bromo-2,6-dichlorophenyl)sulfonyl-N-cyclopropylpiperazine-1-carbothioamide | 4-[4-bromanyl-2,6-bis(chloranyl)phenyl]sulfonyl-N-cyclopropyl-piperazine-1-carbothioamide | MLS002252403 | SMR001314749 | cid_2447421
Type:
Small organic molecule
Emp. Form.:
C14H16BrCl2N3O2S2
Mol. Mass.:
473.236
SMILES:
Clc1cc(Br)cc(Cl)c1S(=O)(=O)N1CCN(CC1)C(=S)NC1CC1
Structure:
Search PDB for entries with ligand similarity: