Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM30698
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM30698
Synonyms:
2-(2,4-dimethoxyanilino)-7-keto-N-(tetrahydrofurfuryl)chromene-3-carboxamide | 2-(2,4-dimethoxyanilino)-7-oxo-N-(2-oxolanylmethyl)-1-benzopyran-3-carboxamide | 2-(2,4-dimethoxyanilino)-7-oxo-N-(oxolan-2-ylmethyl)chromene-3-carboxamide | 2-[(2,4-dimethoxyphenyl)amino]-7-oxidanylidene-N-(oxolan-2-ylmethyl)chromene-3-carboxamide | 2-[(Z)-2,4-Dimethoxy-phenylimino]-7-hydroxy-2H-chromene-3-carboxylic acid (tetrahydro-furan-2-ylmethyl)-amide | MLS000072508 | SMR000002220 | cid_656123
Type:
Small organic molecule
Emp. Form.:
C23H24N2O6
Mol. Mass.:
424.4465
SMILES:
COc1ccc(Nc2oc3cc(=O)ccc3cc2C(=O)NCC2CCCO2)c(OC)c1
Structure:
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