Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM30718
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM30718
Synonyms:
7-(diethylamino)-2-keto-N-(2-pyridyl)chromene-3-carboxamide | 7-(diethylamino)-2-oxidanylidene-N-pyridin-2-yl-chromene-3-carboxamide | 7-(diethylamino)-2-oxo-N-(2-pyridinyl)-1-benzopyran-3-carboxamide | 7-(diethylamino)-2-oxo-N-pyridin-2-ylchromene-3-carboxamide | JMC493759 Compound 3 | MLS000079476 | SMR000039268 | cid_658314
Type:
Small organic molecule
Emp. Form.:
C19H19N3O3
Mol. Mass.:
337.3725
SMILES:
CCN(CC)c1ccc2cc(C(=O)Nc3ccccn3)c(=O)oc2c1
Structure:
Search PDB for entries with ligand similarity: