Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83482
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
>99000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83482
Synonyms:
MLS000089446 | N-(1,3-benzodioxol-5-yl)-3-methyl-6-phenyl-2-imidazo[2,1-b]thiazolecarboxamide | N-(1,3-benzodioxol-5-yl)-3-methyl-6-phenyl-imidazo[2,1-b][1,3]thiazole-2-carboxamide | N-(1,3-benzodioxol-5-yl)-3-methyl-6-phenyl-imidazo[2,1-b]thiazole-2-carboxamide | N-(1,3-benzodioxol-5-yl)-3-methyl-6-phenylimidazo[2,1-b][1,3]thiazole-2-carboxamide | SMR000016534 | cid_3236662
Type:
Small organic molecule
Emp. Form.:
C20H15N3O3S
Mol. Mass.:
377.416
SMILES:
Cc1c(sc2nc(cn12)-c1ccccc1)C(=O)Nc1ccc2OCOc2c1
Structure:
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