Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83631
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
27700±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83631
Synonyms:
2-[2-nitro-4-(trifluoromethyl)anilino]ethyl 2-oxo-2H-chromene-3-carboxylate | 2-[2-nitro-4-(trifluoromethyl)anilino]ethyl 2-oxochromene-3-carboxylate | 2-[[2-nitro-4-(trifluoromethyl)phenyl]amino]ethyl 2-oxidanylidenechromene-3-carboxylate | 2-ketochromene-3-carboxylic acid 2-[2-nitro-4-(trifluoromethyl)anilino]ethyl ester | 2-oxo-1-benzopyran-3-carboxylic acid 2-[2-nitro-4-(trifluoromethyl)anilino]ethyl ester | MLS000833678 | SMR000457199 | cid_2799171
Type:
Small organic molecule
Emp. Form.:
C19H13F3N2O6
Mol. Mass.:
422.3115
SMILES:
[O-][N+](=O)c1cc(ccc1NCCOC(=O)c1cc2ccccc2oc1=O)C(F)(F)F
Structure:
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